Research Articles

Research on Melatonin and Cancer

An Overview of Melatonin and Breast Cancer

Exploring melatonin’s unique effects on breast cancer cells

By Tina Kaczor, ND, FABNO

“…In breast cancer, melatonin is capable of disrupting estrogen-mediated cellular pathways, resulting in a net reduction in estrogenic stimulation of cells. The pineal production of melatonin follows a diurnal rhythm, with peak production at about 2 a.m. Studies have shown that circadian disruption, specifically night shift work, is correlated with an increased risk of developing breast cancer.” READ MORE

Benefits of Melatonin in Solid Tumors When Used Concurrently With Chemotherapy

Melatonin offers a relatively safe option to support patients undergoing active treatment

By Renee Lang, ND, FABNO

“A meta-analysis of 8 randomized controlled trials (RCTs). The incorporated studies were neither blinded nor placebo-controlled. All studies compared a control group receiving standard chemo/radiotherapy to an intervention group receiving the same treatment with the addition of melatonin. The standard treatment was chemotherapy in 6 of the trials, radiotherapy in 1 trial, and transarterial chemoembolization (TACE) in the remaining trial.” READ MORE

 Research on Vitamin D and Cancer

The Latest Research on Vitamin D

Bottom Line Monograph

By Natural Standard

Cancer prevention (breast, colorectal, prostate, other)
Use of vitamin D supplements, alone or in combination with calcium, has been associated with a decreased risk of certain types of cancers. Studies have suggested an inverse association between vitamin D intake (with or without calcium) and colorectal, cervical, breast, and prostate cancers. Overall, there is a lack of consistent evidence to support claims that vitamin D reduces the risk of ovarian or pancreatic cancer occurrence. Also, some research has shown that elevated vitamin D levels or intakes may increase the risk of certain cancers (prostate, breast, pancreatic, and esophageal). Continued evaluation is needed before a clear conclusion can be made.” READ MORE

Vitamin D as Melanoma Treatment

Small doses may provide some benefit

By Jacob Schor, ND, FABNO

“Investigators evaluated blood samples for an association between vitamin D levels and outcome measures in patients with melanoma while controlling for systemic inflammatory response (SIR) based on simultaneous C-reactive protein (CRP) measurements.” READ MORE